The Impact of Maternal Hypothyroidism during Pregnancy on Minipuberty in Boys.

ABSTRACT: Minipuberty is a period of increased reproductive axis activity in infancy, which seems to be implicated in the postnatal development of male genital organs. Impaired thyroid function during pregnancy is associated with an increased risk of prenatal, perinatal, and postnatal complications. The aim of this study was to investigate whether the presence of hypothyroidism during pregnancy modulates the course of male minipuberty. We compared three matched groups of male infants: sons of women with hypothyroidism uncontrolled or poorly controlled during pregnancy (group A), male offspring of women treated over the entire pregnancy with adequate doses of levothyroxine (group B), and sons born to women with no evidence of thyroid disease (group C). Salivary levels of testosterone, androstenedione

SUBMITTER: Kowalcze K 

PROVIDER: S-EPMC10744195 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature