Heart Failure Promotes Cancer Progression in an Integrin β1-Dependent Manner.

ABSTRACT: Heart failure and cancer are currently the deadliest diseases in the Western world, posing the most pressing clinical challenges that remain unmet today. Both conditions share similar risk factors, including age, genetics, lifestyle, chronic inflammation, stress, and more. Furthermore, medications that are being used to counteract cancer frequently result in cardiotoxicity and the spontaneous emergence of heart failure. Thus, heart failure and cancer display an intimate connection and share similarities. Recent studies show that cardiac remodeling and heart failure promote cancer progression and metastasis. Using three different mouse models for heart failure revealed that the communication between the remodeled heart and the tumor is facilitated through multiple secreted factors. Among th

SUBMITTER: Langier Goncalves I 

PROVIDER: S-EPMC10744241 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature