Dose-Dependent Genetic Resistance to Azole Fungicides Found in the Apple Scab Pathogen.

ABSTRACT: The evolution of azole resistance in fungal pathogens presents a major challenge in both crop production and human health. Apple orchards across the world are faced with the emergence of azole fungicide resistance in the apple scab pathogen Venturia inaequalis. Target site point mutations observed in this fungus to date cannot fully explain the reduction in sensitivity to azole fungicides. Here, polygenic resistance to tebuconazole was studied across a population of V. inaequalis. Genotyping by sequencing allowed Quantitative Trait Loci (QTLs) mapping to identify the genetic components controlling this fungicide resistance. Dose-dependent genetic resistance was identified, with distinct genetic components contributing to fungicide resistance at different exposure levels. A QT

SUBMITTER: Heaven T 

PROVIDER: S-EPMC10744243 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature