Transcriptional Reprogramming of Candida tropicalis in Response to Isoespintanol Treatment.

ABSTRACT: Candida tropicalis, an opportunistic pathogen, ranks among the primary culprits of invasive candidiasis, a condition notorious for its resistance to conventional antifungal drugs. The urgency to combat these drug-resistant infections has spurred the quest for novel therapeutic compounds, with a particular focus on those of natural origin. In this study, we set out to evaluate the impact of isoespintanol (ISO), a monoterpene derived from Oxandra xylopioides, on the transcriptome of C. tropicalis. Leveraging transcriptomics, our research aimed to unravel the intricate transcriptional changes induced by ISO within this pathogen. Our differential gene expression analysis unveiled 186 differentially expressed genes (DEGs) in response to ISO, with a striking 85% of these gen

SUBMITTER: Contreras-Martinez OI 

PROVIDER: S-EPMC10744401 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature