Direct Comparative Analysis of a Pharmacogenomics Panel with PacBio Hifi^® Long-Read and Illumina Short-Read Sequencing.

ABSTRACT:

Background

Pharmacogenetics (PGx) aims to determine genetic signatures that can be used in clinical settings to individualize treatment for each patient, including anti-cancer drugs, anti-psychotics, and painkillers. Taken together, a better understanding of the impacts of genetic variants on the corresponding protein function or expression permits the prediction of the pharmacological response: responders, non-responders, and those with adverse drug reactions (ADRs).

Objective

This work provides a comparison between innovative long-read sequencing (LRS) and short-read sequencing (SRS) techniques.

Methods and materials

The gene panel captured using PacBio HiFi^® sequencing was tested on thirteen clinical samples on GENTYANE's platform. SRS, using a comprehen

SUBMITTER: Barthelemy D 

PROVIDER: S-EPMC10744512 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature