Brain-Heart Axis: Brain-Derived Neurotrophic Factor and Cardiovascular Disease-A Review of Systematic Reviews.

ABSTRACT:

Background

The brain-heart axis is an intra- and bidirectional complex that links central nervous system dysfunction and cardiac dysfunction. In recent decades, brain-derived neurotrophic factor (BDNF) has emerged as a strategic molecule involved in both brain and cardiovascular disease (CVD). This systematic review of systematic reviews aimed to (1) identify and summarize the evidence for the BDNF genotype and BDNF concentration in CVD risk assessment, (2) evaluate the evidence for the use of BDNF as a biomarker of CVD recovery, and (3) evaluate rehabilitation approaches that can restore BDNF concentration.

Methods

A comprehensive search strategy was developed using PRISMA. The risk of bias was assessed via ROBIS.

Results

Seven studies were identified, most of which

SUBMITTER: Fioranelli M 

PROVIDER: S-EPMC10744648 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature