High Structural Diversity of Aeruginosins in Bloom-Forming Cyanobacteria of the Genus <i>Planktothrix</i> as a Consequence of Multiple Recombination Events.

ABSTRACT: Many compounds produced by cyanobacteria act as serine protease inhibitors, such as the tetrapeptides aeruginosins (Aer), which are found widely distributed. The structural diversity of Aer is intriguingly high. However, the genetic basis of this remains elusive. In this study, we explored the genetic basis of Aer synthesis among the filamentous cyanobacteria Planktothrix spp. In total, 124 strains, isolated from diverse freshwater waterbodies, have been compared regarding variability within Aer biosynthesis genes and the consequences for structural diversity. The high structural variability could be explained by various recombination processes affecting Aer synthesis, above all, the acquisition of accessory enzymes involved in post synthesis modification of the Aer peptide (e.g., h

SUBMITTER: Entfellner E 

PROVIDER: S-EPMC10744761 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature