Miltiradiene Production by Cytoplasmic Metabolic Engineering in Nicotiana benthamiana.

ABSTRACT: Plant natural products are important sources of innovative drugs, but the extraction and isolation of medicinal natural products from plants is challenging as these compounds have complex structures that are difficult to synthesize chemically. Therefore, utilizing heterologous expression systems to produce medicinal natural products in plants is a novel, environmentally friendly, and sustainable method. In this study, Nicotiana benthamiana was used as the plant platform to successfully produce miltiradiene, the key intermediate of tanshinones, which are the bioactive constituents of the Chinese medicinal plant Salvia miltiorrhiza. The yield of miltiradiene was increased through cytoplasmic engineering strategies combined with the enhancement of isoprenoid precursors. Addition

SUBMITTER: Ren X 

PROVIDER: S-EPMC10745046 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature