Technical Report: A Comprehensive Comparison between Different Quantification Versions of Nightingale Health's ¹H-NMR Metabolomics Platform.

ABSTRACT: ¹H-NMR metabolomics data is increasingly used to track health and disease. Nightingale Health, a major supplier of ¹H-NMR metabolomics, has recently updated the quantification strategy to further align with clinical standards. Such updates, however, might influence backward replicability, particularly affecting studies with repeated measures. Using data from BBMRI-NL consortium (~28,000 samples from 28 cohorts), we compared Nightingale data, originally released in 2014 and 2016, with a re-quantified version released in 2020, of which both versions were based on the same NMR spectra. Apart from two discontinued and twenty-three new analytes, we generally observe a high concordance between quantification versions with 73 out of 222 (33%) analytes showing a mean ρ > 0.9

SUBMITTER: Bizzarri D 

PROVIDER: S-EPMC10745109 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature