Efficient post-synthesis incorporation and conjugation of reactive ketones in RNA via 2'-acylation.

ABSTRACT: Despite the broad utility of ketones in bioconjugation, few methods exist to introduce them into RNA. Here we develop highly reactive 2'-OH acylating reagents containing strained-ring ketones, and employ them as versatile labeling handles for RNA.

SUBMITTER: Shioi R 

PROVIDER: S-EPMC10745195 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature