Synthesis of Six-Membered N-Heterocyclic Carbene Precursors Based on Camphor.

ABSTRACT: The endo- and exo-N-heterocyclic carbene precursors based on camphor were prepared diastereoselectively in five synthetic steps starting from (1S)-(+)-ketopinic acid. The obtained N-heterocyclic carbene precursors were investigated in an asymmetric benzoin reaction. All new compounds were fully characterized, and the absolute configurations were determined via X-ray diffraction and NOESY measurements.

SUBMITTER: Segina J 

PROVIDER: S-EPMC10745536 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature