A Combination of Blue Light at 460 nm and H₂O₂ for the Safe and Effective Eradication of Staphylococcus aureus in an Infected Mouse Skin Abrasion Model.

ABSTRACT: Antibiotic-free approaches are more important than ever to address the rapidly growing problem of the antibiotic resistance crisis. The photolysis of the bacterial virulence factor staphyloxanthin using blue light at 460 nm (BL460 nm) has been found to effectively attenuate Staphylococcus aureus to chemical and physical agents. However, phototherapy using BL640 nm still needs to be investigated in detail for its safety in eradicating Staphylococcus aureus in vitro and in vivo. In this study, we employed a 460 nm continuous-wavelength LED source and a low concentration of hydrogen peroxide to treat S. aureus under a culturing condition and a wound abrasion mouse model. The results demonstrated the safety of the combined therapy when it did not modify the bacterial virul

SUBMITTER: Ngo VN 

PROVIDER: S-EPMC10745725 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature