Enteropathogenic E. coli infection co-elicits lysosomal exocytosis and lytic host cell death.

ABSTRACT:

Importance

Enteropathogenic Escherichia coli (EPEC) infection is a significant cause of gastroenteritis, mainly in children. Therefore, studying the mechanisms of EPEC infection is an important research theme. EPEC modulates its host cell life by injecting via a type III secretion machinery cell death modulating effector proteins. For instance, while EspF and Map promote mitochondrial cell death, EspZ antagonizes cell death. We show that these effectors also control lysosomal exocytosis, i.e., the trafficking of lysosomes to the host cell plasma membrane. Interestingly, the capacity of these effectors to induce or protect against cell death correlates completely with their ability to induce LE, suggesting that the two processes are interconnected. Modulating host cell death

SUBMITTER: Shtuhin-Rahav R 

PROVIDER: S-EPMC10746156 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature