REC protein family expansion by the emergence of a new signaling pathway.

ABSTRACT:

Importance

We explore when and why large classes of proteins expand into new sequence space. We used an unsupervised machine learning approach to observe the sequence landscape of REC domains of bacterial response regulator proteins. We find that within-gene recombination can switch effector domains and, consequently, change the regulatory context of the duplicated protein.

SUBMITTER: Garber ME 

PROVIDER: S-EPMC10746176 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature