Ubiquitination of Sec22b by a novel Legionella pneumophila ubiquitin E3 ligase.

ABSTRACT:

Importance

Protein ubiquitination is one of the most important post-translational modifications that plays critical roles in the regulation of a wide range of eukaryotic signaling pathways. Many successful intracellular bacterial pathogens can hijack host ubiquitination machinery through the action of effector proteins that are injected into host cells by secretion systems. Legionella pneumophila is the etiological agent of legionellosis that is able to survive and replicate in various host cells. The defective in organelle trafficking (Dot)/intracellular multiplication (Icm) type IV secretion system of L. pneumophila injects over 330 effectors into infected cells to create an optimal environment permissive for its intracellul

SUBMITTER: Ma K 

PROVIDER: S-EPMC10746214 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature