Transcending the challenge of evolving resistance mechanisms in <i>Pseudomonas aeruginosa</i> through β-lactam-enhancer-mechanism-based cefepime/zidebactam.

ABSTRACT: Compared to other genera of Gram-negative pathogens, Pseudomonas is adept in acquiring complex non-enzymatic and enzymatic resistance mechanisms thus remaining a challenge to even novel antibiotics including recently developed β-lactam and β-lactamase inhibitor combinations. This study shows that the novel β-lactam enhancer approach enables cefepime/zidebactam to overcome both non-enzymatic and enzymatic resistance mechanisms associated with a challenging panel of P. aeruginosa. This study highlights that the β-lactam enhancer mechanism is a promising alternative to the conventional β-lactam/β-lactamase inhibitor approach in combating ever-evolving MDR P. aeruginosa.

SUBMITTER: Hujer AM 

PROVIDER: S-EPMC10746216 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature