Contrasting roles of MERS-CoV and SARS-CoV-2 internal proteins in pathogenesis in mice.

ABSTRACT:

Importance

The function of betacoronavirus internal protein has been relatively understudied. The earliest report on the internal protein of mouse hepatitis virus suggested that the internal protein is a structural protein without significant functions in virus replication and virulence. However, the internal proteins of severe acute respiratory syndrome coronavirus (SARS-CoV), Middle-East respiratory syndrome coronavirus, and SARS-CoV-2 have been shown to evade immune responses. Despite the reported functions of the internal protein in these highly pathogenic human coronaviruses, its role in mediating pathogenesis in experimentally infected animals has not been characterized. Our data indicated that despite the similar genomic location and expres

SUBMITTER: Wong L-YR 

PROVIDER: S-EPMC10746224 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature