Peroxisome dynamics determines host-derived ROS accumulation and infectious growth of the rice blast fungus.

ABSTRACT:

Importance

The interplay between plant and pathogen is a dynamic process, with the host's innate defense mechanisms serving a crucial role in preventing infection. In response to many plant pathogen infections, host cells generate the key regulatory molecule, reactive oxygen species (ROS), to limit the spread of the invading organism. In this study, we reveal the effects of fungal peroxisome dynamics on host ROS homeostasis, during the rice blast fungus Magnaporthe oryzae infection. The elongation of the peroxisome appears contingent upon ROS and links to the accumulation of ROS within the host and the infectious growth of the pathogen. Importantly, we identify a peroxisomal 3-ketoacyl-CoA thiolase, MoKat2, responsible for the elongation of the peroxisome during the infectio

SUBMITTER: Zhang J 

PROVIDER: S-EPMC10746245 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature