Pervasive gene deregulation underlies adaptation and maladaptation in trimethoprim-resistant <i>E. coli</i>.

ABSTRACT:

Importance

Bacteria employ a number of mechanisms to adapt to antibiotics. Mutations in transcriptional regulators alter the expression levels of genes that can change the susceptibility of bacteria to antibiotics. Two-component signaling proteins are a major class of signaling molecule used by bacteria to regulate transcription. In previous work, we found that mutations in MgrB, a feedback regulator of the PhoQP two-component system, conferred trimethoprim tolerance to Escherichia coli. Here, we elucidate how mutations in MgrB have a domino-like effect on the gene regulatory network of E. coli. As a result, pervasive perturbation of gene regulation ensues. Depending on the environmental context, this pervasive deregulation is either adaptive or maladaptive. Our study

SUBMITTER: Vinchhi R 

PROVIDER: S-EPMC10746255 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature