Candida albicans resistance to hypochlorous acid.

ABSTRACT:

Importance

Hypochlorous acid (HOCl), commonly known as bleach, is generated during the respiratory burst by phagocytes and is a key weapon used to attack Candida albicans and other microbial pathogens. However, the effects of hypochlorous acid on C. albicans have been less well studied than H₂O₂, a different type of oxidant produced by phagocytes. HOCl kills C. albicans more effectively than H₂O₂ and results in disruption of the plasma membrane. HOCl induced a very different transcriptional response than H₂O₂, and there were significant differences in the susceptibility of mutant strains of C. albicans to these oxidants. Altogether, these results indicate that HOCl has distinct effects on

SUBMITTER: Douglas LM 

PROVIDER: S-EPMC10746268 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature