HTLV-1 biofilm polarization maintained by tetraspanin CD82 is required for efficient viral transmission.

ABSTRACT:

Importance

In the early stages of infection, human T-lymphotropic virus type 1 (HTLV-1) dissemination within its host is believed to rely mostly on cell-to-cell contacts. Past studies unveiled a novel mechanism of HTLV-1 intercellular transmission based on the remodeling of the host-cell extracellular matrix and the generation of cell-surface viral assemblies whose structure, composition, and function resemble bacterial biofilms. These polarized aggregates of infectious virions, identified as viral biofilms, allow the bulk delivery of viruses to target cells and may help to protect virions from immune attacks. However, viral biofilms' molecular and functional description is still in its infancy, although it is crucial to fully decipher retrovirus pathogenesis. Here, we explore the

SUBMITTER: Arone C 

PROVIDER: S-EPMC10746275 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature