Platelet-inspired synthetic nanoparticles improve hemostasis and hemodynamics in a rabbit model of abdominal hemorrhage.

ABSTRACT:

Background

Early platelet transfusion is associated with reduced mortality in traumatic hemorrhage. However, platelet usage is severely limited because of the challenges of donor availability, platelet portability, and storage. Here, we report on a bioinspired synthetic platelet (SP) nanoconstruct that utilizes liposome surface-decoration with peptides that mimic injury site-specific platelet adhesion to von Willebrand Factor and collagen, and fibrinogen-mediated platelet aggregation. Synthetic platelet has previously shown promising hemostatic outcomes in vitro and in vivo. Here, we evaluated hemostasis and hemodynamic effects of SP in a rabbit model of abdominal hemorrhage.

Methods

Twenty-three adult male New Zealand white rabbits (2.5-3.5 kg) were treated with either buff

SUBMITTER: Srinivasan AJ 

PROVIDER: S-EPMC10746291 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature