Association of pulse pressure with death, myocardial infarction, and stroke among cardiovascular outcome trial participants.

ABSTRACT:

Background

Prior evidence demonstrates that pulse pressure (PP), a surrogate marker of arterial stiffness, is an independent risk factor for mortality and major adverse cardiovascular (CV) events.

Objectives

The study aimed to identify the association of PP with death, myocardial infarction, and stroke among participants enrolled in large CV outcome clinical trials and determine if this association was impacted by pre-existing CV disease, or specific CV risk factors.

Methods

A total of 65,382 individuals, ages 19 to 98 years, that were enrolled in one of five CV outcome trials were analyzed. Baseline demographics, history, blood pressures, and medications were collected. Univariate and multivariable analyses were conducted to explore temporal patterns, risks, and adju

SUBMITTER: Agarwal N 

PROVIDER: S-EPMC10746405 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature