Parishin treatment alleviates cardiac aging in naturally aged mice.

ABSTRACT:

Background

Cardiac aging progressively decreases physiological function and drives chronic/degenerative aging-related heart diseases. Therefore, it is crucial to postpone the aging process of heart and create products that combat aging.

Aims & methods

The objective of this study is to examine the effects of parishin, a phenolic glucoside isolated from traditional Chinese medicine Gastrodia elata, on anti-aging and its underlying mechanism. To assess the senescent biomarkers, cardiac function, cardiac weight/body weight ratio, cardiac transcriptomic changes, and cardiac histopathological features, heart tissue samples were obtained from young mice (12 weeks), aged mice (19 months) treated with parishin, and aged mice that were not treated.

Results

Parishin treat

SUBMITTER: Zhou S 

PROVIDER: S-EPMC10746429 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature