Identification of a novel ferroptosis-related gene signature associated with retinal degeneration induced by light damage in mice.

ABSTRACT:

Background

Neurodegenerative retinal diseases such as retinitis pigmentosa are serious disorders that may cause irreversible visual impairment. Ferroptosis is a novel type of programmed cell death, and the involvement of ferroptosis in retinal degeneration is still unclear. This study aimed to investigate the related ferroptosis genes in a mice model of retinal degeneration induced by light damage.

Methods

A public dataset of GSE10528 deriving from the Gene Expression Omnibus database was analyzed to identify the differentially expressed genes (DEGs). Gene set enrichment analysis between light damage and control group was conducted. The differentially expressed ferroptosis-related genes (DE-FRGs) were subsequently identified by intersecting the DEGs with a ferroptosis genes

SUBMITTER: Lei XL 

PROVIDER: S-EPMC10746433 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature