Understanding the consequences of leisure sedentary behavior on periodontitis: A two-step, multivariate Mendelian randomization study.

ABSTRACT:

Background

The relationship between leisure sedentary behavior (LSB) and periodontitis risk remains unclear in terms of causality and the potential mediating effects of intermediate factors.

Materials and methods

Using the aggregate data of several large-scale genetic association studies from participants of European descent, we conducted a univariate, two-step, and multivariate Mendelian random (MR) analysis to infer the overall effect of LSB on periodontitis, and quantified the intermediary proportion of intermediary traits such as smoking.

Results

Our findings indicated that per 1-SD increase (1.87 h) in leisure screen time (LST), there was a 23 % increase in the risk of periodontitis. [odds ratios (95 % CI) = 1.23 (1.04-1.44), p = 0.013]. Smoking was found to part

SUBMITTER: Zhang Z 

PROVIDER: S-EPMC10746448 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature