Development of a highly concentrated collagen ink for the creation of a 3D printed meniscus.

ABSTRACT: The most prevalent extracellular matrix (ECM) protein in the meniscus is collagen, which controls cell activity and aids in preserving the biological and structural integrity of the ECM. To create stable and high-precision 3D printed collagen scaffolds, ink formulations must possess good printability and cytocompatibility. This study aims to overlap the limitation in the 3D printing of pure collagen, and to develop a highly concentrated collagen ink for meniscus fabrication. The extrusion test revealed that 12.5 % collagen ink had the best combination of high collagen concentration and printability. The ink was specifically designed to have load-bearing capacity upon printing and characterized with respect to rheological and extrusion properties. Following printing of structures with diffe

SUBMITTER: Ronca A 

PROVIDER: S-EPMC10746456 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature