SOX10 promotes the malignant biological behavior of basal-like breast cancer cells by regulating EMT process.

ABSTRACT:

Background

The diagnostic utility of SRY-box transcription factor 10 (SOX10) expression in basal-like breast cancer (BLBC) has been reported previously. However, the effect of SOX10 on the malignancy of BLBC cells and the underlying molecular mechanisms remain unelucidated. Here, we investigate the regulatory mechanisms and roles of SOX10 in BLBC progression.

Methods

Sequencing data from patients with BLBC were extracted from the Cancer Genome Atlas database to determine the transcriptomic levels of SOX10 across breast cancer subtypes. Subsequently, the bioinformatics relevance of SOX10 in BLBC was investigated. Immunohistochemical assays were used to corroborate the protein expression of SOX10 in clinicopathological specimens (human breast cancer paraffin tissues). RNA inte

SUBMITTER: Yang K 

PROVIDER: S-EPMC10746469 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature