Supercritical fluid (SCF)-assisted preparation of cyclodextrin-based poly(pseudo)rotaxanes for transdermal purposes.

ABSTRACT: This study aims to investigate the effect of the preparation of solid dispersions using supercritical CO₂ (scCO₂) on the physicochemical properties and the performance of supramolecular gels based on polymer-cyclodextrin (CD) interactions (named poly(pseudo)rotaxanes, PPR) envisaging a transdermal administration. Solid dispersions containing Soluplus^®, the antihypertensive drug carvedilol (CAR), and CD (αCD or HPβCD) were prepared and characterized by HPLC, XRPD, FTIR, and DSC. PPRs prepared from solid dispersions (SCF gels) and the corresponding physical mixtures (PM gels) were analyzed regarding rheology, morphology, in vitro drug diffusion, and ex vivo drug skin permeation. The application of scCO₂ led to the loss of the crystalline lattice of

SUBMITTER: Cardoso G 

PROVIDER: S-EPMC10746585 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature