Factors Associated with Geographical Variability of Antimicrobial Use in Japan.

ABSTRACT:

Introduction

Evidence regarding the factors affecting the geographical variation of antimicrobial use (AMU) is relatively scarce. This study aimed to evaluate factors potentially associated with geographical variability of AMU per day per 1000 habitants in the 47 prefectures of Japan.

Methods

This is an observational ecological study using the Japanese national database in 2019. The outcome was the defined daily doses per 1000 inhabitants per day by prefecture. Multivariable negative binomial regression analysis was conducted using patient- and physician-level variables.

Results

The study included 605,391,054 defined daily doses of AMU in 2019 from the 47 prefectures. In the multivariable negative binomial regression analyses for the outcome of total AMU, the proporti

SUBMITTER: Kitano T 

PROVIDER: S-EPMC10746630 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature