Loss-of-function cancer-linked mutations in the EIF4G2 non-canonical translation initiation factor.

ABSTRACT: Tumor cells often exploit the protein translation machinery, resulting in enhanced protein expression essential for tumor growth. Since canonical translation initiation is often suppressed because of cell stress in the tumor microenvironment, non-canonical translation initiation mechanisms become particularly important for shaping the tumor proteome. EIF4G2 is a non-canonical translation initiation factor that mediates internal ribosome entry site (IRES)- and uORF-dependent initiation mechanisms, which can be used to modulate protein expression in cancer. Here, we explored the contribution of EIF4G2 to cancer by screening the COSMIC database for EIF4G2 somatic mutations in cancer patients. Functional examination of missense mutations revealed deleterious effects on EIF4G2 protein-protein i

SUBMITTER: Meril S 

PROVIDER: S-EPMC10746786 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature