Renalase is a novel, soluble monoamine oxidase that regulates cardiac function and blood pressure.

ABSTRACT: The kidney not only regulates fluid and electrolyte balance but also functions as an endocrine organ. For instance, it is the major source of circulating erythropoietin and renin. Despite currently available therapies, there is a marked increase in cardiovascular morbidity and mortality among patients suffering from end-stage renal disease. We hypothesized that the current understanding of the endocrine function of the kidney was incomplete and that the organ might secrete additional proteins with important biological roles. Here we report the identification of a novel flavin adenine dinucleotide-dependent amine oxidase (renalase) that is secreted into the blood by the kidney and metabolizes catecholamines in vitro (renalase metabolizes dopamine most efficiently, followed by epinephrine, a

SUBMITTER: Xu J 

PROVIDER: S-EPMC1074681 | biostudies-literature | 2005 May

REPOSITORIES: biostudies-literature