Ontology highlight
ABSTRACT:
SUBMITTER: Lin Y
PROVIDER: S-EPMC10746944 | biostudies-literature | 2023 Dec
REPOSITORIES: biostudies-literature
Lin Yujian Y Zhang Lei L Gao Mengyue M Tang Zixin Z Cheng Xiang X Li Haoming H Qin Jianbing J Tian Meiling M Jin Guohua G Zhang Xinhua X Li Wen W
Journal of cellular and molecular medicine 20231017 24
Amyloid-β<sub>1-42</sub> (Aβ<sub>1-42</sub> ) is strongly associated with Alzheimer's disease (AD). The aim of this study is to elucidate whether and how miR-6076 participates in the modulation of amyloid-β (Aβ)-induced neuronal damage. To construct the neuronal damage model, SH-SY5Y cells were treated with Aβ<sub>1-42</sub> . By qRT-PCR, we found that miR-6076 is significantly upregulated in Aβ<sub>1-42</sub> -treated SH-SY5Y cells. After miR-6076 inhibition, p-Tau and apoptosis levels were dow ...[more]