Triphenylphosphine Derivatives of Allylbenzenes Express Antitumor and Adjuvant Activity When Solubilized with Cyclodextrin-Based Formulations.

ABSTRACT: Allylbenzenes (apiol, dillapiol, myristicin and allyltetramethoxybenzene) are individual components of plant essential oils that demonstrate antitumor activity and can enhance the antitumor activity of cytotoxic drugs, such as paclitaxel, doxorubicin, cisplatin, etc. Triphenylphosphine (PPh₃) derivatives of allylbenzenes are two to three orders of magnitude more potent than original allylbenzenes in terms of IC₅₀. The inhibition of efflux pumps has been reported for allylbenzenes, and the PPh₃ moiety is deemed to be responsible for preferential mitochondrial accumulation and the depolarization of mitochondrial membranes. However, due to poor solubility, the practical use of these substances has never been an option. Here, we show that this problem can be so

SUBMITTER: Zlotnikov ID 

PROVIDER: S-EPMC10747112 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature