The Synthesis and Antibacterial Properties of Pillar[5]arene with Streptocide Fragments.

ABSTRACT: The growing problem of bacterial resistance to antimicrobials actualizes the development of new approaches to solve this challenge. Supramolecular chemistry tools can overcome the limited bacterial resistance and side effects of classical sulfonamides that hinder their use in therapy. Here, we synthesized a number of pillar[5]arenes functionalized with different substituents, determined their ability to self-association using DLS, and characterized antimicrobial properties against S. typhimurium, K. pneumoniae, P. aeruginosa, S. epidermidis, S. aureus via a resazurin test. Biofilm prevention concentration was calculated for an agent with established antimicrobial activity by the crystal-violet staining method. We evaluated the mutagenicity of the macrocyc

SUBMITTER: Subakaeva E 

PROVIDER: S-EPMC10747162 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature