Quality Assessment of Selected Protein Structures Derived from Homology Modeling and AlphaFold.

ABSTRACT: With technology advancing, many prediction algorithms have been developed to facilitate the modeling of inherently dynamic and flexible macromolecules such as proteins. Improvements in the prediction of protein structures have attracted a great deal of attention due to the advantages they offer, e.g., in drug design. While trusted experimental methods, such as X-ray crystallography, NMR spectroscopy, and electron microscopy, are preferred structure analysis techniques, in silico approaches are also being widely used. Two computational methods, which are on opposite ends of the spectrum with respect to their modus operandi, i.e., homology modeling and AlphaFold, have been established to provide high-quality structures. Here, a comparative study of the quality of structures either predicted

SUBMITTER: Binbay FA 

PROVIDER: S-EPMC10747200 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature