SARS-CoV-2 Vaccine Effectiveness in Hospitalized Patients: A Multicenter Test-Negative Case-Control Study.

ABSTRACT:

Background

Phase III clinical trials have documented the efficacy of the SARS-CoV-2 vaccines in preventing symptomatic COVID-19. Nonetheless, it is imperative to continue analyzing the clinical response to different vaccines in real-life studies. Our objective was to evaluate the effectiveness of five different vaccines in hospitalized patients with COVID-19 during the third COVID-19 outbreak in Mexico dominated by the Delta variant.

Methods

A test-negative case-control study was performed in nine tertiary-care hospitals for COVID-19. We estimated odds ratios (OR) adjusted by variables related a priori with the likelihood of SARS-CoV-2 infection and its severity.

Results

We studied 761 subjects, 371 cases, and 390 controls with a mean age of 53 years (SD, 17 years). O

SUBMITTER: Thirion-Romero I 

PROVIDER: S-EPMC10747324 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature