ATG8f Interacts with Chilli Veinal Mottle Virus 6K2 Protein to Limit Virus Infection.

ABSTRACT: Autophagy, as a conserved protein degradation pathway in plants, has also been reported to be intricately associated with antiviral defense mechanisms. However, the relationship between chilli veinal mottle virus (ChiVMV) and autophagy has not been investigated in the existing research. Here, we reveal that ChiVMV infection caused the accumulation of autophagosomes in infected Nicotiana benthamiana leaves and the upregulation of autophagy-related genes (ATGs). Moreover, the changes in gene expression were correlated with the development of symptoms. Treatment with autophagy inhibitors (3-MA or E-64D) could increase the infection sites and facilitate virus infection, whereas treatment with the autophagy activator (Rapamycin) limited virus infection. Then, ATG8f was identified

SUBMITTER: Ji C 

PROVIDER: S-EPMC10747504 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature