Breaking the Silence: Regulation of HIV Transcription and Latency on the Road to a Cure.

ABSTRACT: Antiretroviral therapy (ART) has brought the HIV/AIDS epidemic under control, but a curative strategy for viral eradication is still needed. The cessation of ART results in rapid viral rebound from latently infected CD4+ T cells, showing that control of viral replication alone does not fully restore immune function, nor does it eradicate viral reservoirs. With a better understanding of factors and mechanisms that promote viral latency, current approaches are primarily focused on the permanent silencing of latently infected cells ("block and lock") or reactivating HIV-1 gene expression in latently infected cells, in combination with immune restoration strategies to eliminate HIV infected cells from the host ("shock and kill"). In this review, we provide a summary of the current, most promis

SUBMITTER: Duggan NN 

PROVIDER: S-EPMC10747579 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature