The Synthesis, In Vitro Bio-Evaluation, and In Silico Molecular Docking Studies of Pyrazoline-Thiazole Hybrid Analogues as Promising Anti-α-Glucosidase and Anti-Urease Agents.

ABSTRACT: In the present work, a concise library of benzothiazole-derived pyrazoline-based thiazole (1-17) was designed and synthesized by employing a multistep reaction strategy. The newly synthesized compounds were screened for their α-glucosidase and urease inhibitory activities. The scaffolds (1-17) were characterized using a combination of several spectroscopic techniques, including FT-IR, ¹H-NMR, ¹³C-NMR, and EI-MS. The majority of the synthesized compounds demonstrated a notable potency against α-glucosidase and urease enzymes. These analogues disclosed varying degrees of α-glucosidase and urease inhibitory activities, with their IC₅₀ values ranging from 2.50 to 17.50 μM (α-glucosidase) and 14.30 to 41.50 (ureas

SUBMITTER: Khan Y 

PROVIDER: S-EPMC10747725 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature