A Second Career for p53 as A Broad-Spectrum Antiviral?

ABSTRACT: As the world exits the global pandemic caused by the previously unknown SARS-CoV-2, we also mark the 30th anniversary of p53 being named "molecule of the year" by Science based on its role as a tumor suppressor. Although p53 was originally discovered in association with a viral protein, studies on its role in preventing carcinogenesis have far overshadowed research related to p53's role in viral infections. Nonetheless, there is an extensive body of scientific literature demonstrating that p53 is a critical component of host immune responses to viral infections. It is striking that diverse viruses have independently developed an impressive repertoire of varied mechanisms to counter the host defenses that are mediated by and through p53. The variety of ways developed by viruses to di

SUBMITTER: Harford JB 

PROVIDER: S-EPMC10747836 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature