Towards Antibacterial Agents: Synthesis and Biological Activity of Multivalent Amide Derivatives of Thiacalix[4]arene with Hydroxyl and Amine Groups.

ABSTRACT: Antimicrobial resistance to modern antibiotics stimulates the search for new ways to synthesize and modify antimicrobial drugs. The development of synthetic approaches that can easily change different fragments of the molecule is a promising solution to this problem. In this work, a synthetic approach was developed to obtain multivalent thiacalix[4]arene derivatives containing different number of amine and hydroxyl groups. A series of macrocyclic compounds in cone, partial cone, and 1,3-alternate stereoisomeric forms containing -NHCH₂CH₂R (R = NH₂, N(CH₃)₂, and OH) and -N(CH₂CH₂OH)₂ terminal fragments, and their model non-macrocyclic analogues were obtained. The antibacterial

SUBMITTER: Shiabiev I 

PROVIDER: S-EPMC10747887 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature