Preparation of ¹⁸F-Labeled Tracers Targeting Fibroblast Activation Protein via Sulfur [¹⁸F]Fluoride Exchange Reaction.

ABSTRACT: Early detection and treatment of cancers can significantly increase patient prognosis and enhance the quality of life of affected patients. The emerging significance of the tumor microenvironment (TME) as a new frontier for cancer diagnosis and therapy may be exploited by radiolabeled tracers for diagnostic imaging techniques such as positron emission tomography (PET). Cancer-associated fibroblasts (CAFs) within the TME are identified by biomarkers such as fibroblast activation protein alpha (FAPα), which are expressed on their surfaces. Targeting FAPα using small-molecule ¹⁸F-labeled inhibitors (FAPIs) has recently garnered significant attention for non-invasive tumor visualization using PET. Herein, two potent aryl-fluorosulfate-based FAPIs, 12 and 13, were synth

SUBMITTER: Craig A 

PROVIDER: S-EPMC10747913 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature