Physiologically Based Pharmacokinetic Modeling in Neonates: Current Status and Future Perspectives.

ABSTRACT: Rational drug use in special populations is a clinical problem that doctors and pharma-cists must consider seriously. Neonates are the most physiologically immature and vulnerable to drug dosing. There is a pronounced difference in the anatomical and physiological profiles be-tween neonates and older people, affecting the absorption, distribution, metabolism, and excretion of drugs in vivo, ultimately leading to changes in drug concentration. Thus, dose adjustments in neonates are necessary to achieve adequate therapeutic concentrations and avoid drug toxicity. Over the past few decades, modeling and simulation techniques, especially physiologically based pharmacokinetic (PBPK) modeling, have been increasingly used in pediatric drug development and clinical therapy. This rigorously designe

SUBMITTER: Zhang W 

PROVIDER: S-EPMC10747965 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature