Temoporfin-Conjugated Upconversion Nanoparticles for NIR-Induced Photodynamic Therapy: Studies with Pancreatic Adenocarcinoma Cells In Vitro and In Vivo.

ABSTRACT: Upconverting nanoparticles are interesting materials that have the potential for use in many applications ranging from solar energy harvesting to biosensing, light-triggered drug delivery, and photodynamic therapy (PDT). One of the main requirements for the particles is their surface modification, in our case using poly(methyl vinyl ether-alt-maleic acid) (PMVEMA) and temoporfin (THPC) photosensitizer to ensure the colloidal and chemical stability of the particles in aqueous media and the formation of singlet oxygen after NIR irradiation, respectively. Codoping of Fe²⁺, Yb³⁺, and Er³⁺ ions in the NaYF₄ host induced upconversion emission of particles in the red region, which is dominant for achieving direct excitation of THPC. Novel monodis

SUBMITTER: Shapoval O 

PROVIDER: S-EPMC10748036 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature