The Role of α3β1 Integrin Modulation on Fabry Disease Podocyte Injury and Kidney Impairment.

ABSTRACT: Podocyte dysfunction plays a crucial role in renal injury and is identified as a key contributor to proteinuria in Fabry disease (FD), primarily impacting glomerular filtration function (GFF). The α3β1 integrins are important for podocyte adhesion to the glomerular basement membrane, and disturbances in these integrins can lead to podocyte injury. Therefore, this study aimed to assess the effects of chloroquine (CQ) on podocytes, as this drug can be used to obtain an in vitro condition analogous to the FD. Murine podocytes were employed in our experiments. The results revealed a dose-dependent reduction in cell viability. CQ at a sub-lethal concentration (1.0 µg/mL) induced lysosomal accumulation significantly (p < 0.0001). Morphological changes were evident through scanning electro

SUBMITTER: Bosquetti B 

PROVIDER: S-EPMC10748128 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature