Amino Acid-Based Boron Carriers in Boron Neutron Capture Therapy (BNCT).

ABSTRACT: Interest in the design of boronated amino acids has emerged, partly due to the utilization of boronophenylalanine (BPA), one of the two agents employed in clinical Boron Neutron Capture Therapy (BNCT). The boronated amino acids synthesized thus far for BNCT investigations can be classified into two categories based on the source of boron: boronic acids or carboranes. Amino acid-based boron carriers, employed in the context of BNCT treatment, demonstrate significant potential in the treatment of challenging tumors, such as those located in the brain. This review aims to shed light on the developmental journey and challenges encountered over the years in the field of amino acid-based boron delivery compound development. The primary focus centers on the utilization of the large amino acid tra

SUBMITTER: Jarvinen J 

PROVIDER: S-EPMC10748186 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature