DNA Damage by Radiopharmaceuticals and Mechanisms of Cellular Repair.

ABSTRACT: DNA is an organic molecule that is highly vulnerable to chemical alterations and breaks caused by both internal and external factors. Cells possess complex and advanced mechanisms, including DNA repair, damage tolerance, cell cycle checkpoints, and cell death pathways, which together minimize the potentially harmful effects of DNA damage. However, in cancer cells, the normal DNA damage tolerance and response processes are disrupted or deregulated. This results in increased mutagenesis and genomic instability within the cancer cells, a known driver of cancer progression and therapeutic resistance. On the other hand, the inherent instability of the genome in rapidly dividing cancer cells can be exploited as a tool to kill by imposing DNA damage with radiopharmaceuticals. As the field of targ

SUBMITTER: Khazaei Monfared Y 

PROVIDER: S-EPMC10748326 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature