Hosts and Heterologous Expression Strategies of Recombinant Toxins for Therapeutic Purposes.

ABSTRACT: The production of therapeutic recombinant toxins requires careful host cell selection. Bacteria, yeast, and mammalian cells are common choices, but no universal solution exists. Achieving the delicate balance in toxin production is crucial due to potential self-intoxication. Recombinant toxins from various sources find applications in antimicrobials, biotechnology, cancer drugs, and vaccines. "Toxin-based therapy" targets diseased cells using three strategies. Targeted cancer therapy, like antibody-toxin conjugates, fusion toxins, or "suicide gene therapy", can selectively eliminate cancer cells, leaving healthy cells unharmed. Notable toxins from various biological sources may be used as full-length toxins, as plant (saporin) or animal (melittin) toxins, or as isolated domains that are ty

SUBMITTER: di Leandro L 

PROVIDER: S-EPMC10748335 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature