CX₃CR1 modulates SLE-associated glomerulonephritis and cardiovascular disease in MRL/lpr mice.

ABSTRACT:

Objective

Patients with systemic lupus erythematosus (SLE) often develop multi-organ damages including heart and kidney complications. We sought to better define the underlying mechanisms with a focus on the chemokine receptor CX₃CR1.

Methods

We generated Cx3cr1-deficient MRL/lpr lupus-prone mice through backcrossing. We then employed heterozygous intercross to generate MRL/lpr littermates that were either sufficient or deficient of CX₃CR1. The mice were also treated with either Lactobacillus spp. or a high-fat diet (HFD) followed by assessments of the kidney and heart, respectively.

Results

Cx3cr1^-/- MRL/lpr mice exhibited a distinct phenotype of exacerbated glomerulonephritis compared to Cx3cr1^+/+ littermates, which was as

SUBMITTER: Cabana-Puig X 

PROVIDER: S-EPMC10748465 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature